Basophils

Julen Lux Baranano

edited by

Joshua Klemt,

Julius Loges,

1. Definition
2. Physiology
3. Function

1. Definition

Basophils are a type of white blood cell (leukocyte) that belong to the myeloid lineage of the immune system and represent less than 1% of total leukocytes in the bloodstream, typically measuring between 10-14 µm in diameter.

2. Physiology

Normal Basophil Count
- Absolute Number: 0-300 cells per microliter (µL) of blood
- Percentage: Typically less than 1% of the total white blood cell (leukocyte) count
Basophilia: high basophil count exceeds 300 cells/µL
Basopenia: low basophil count below the normal range

3. Function

Allergic Reactions
- Release histamine and other mediators in response to allergens, contributing to the inflammatory response
Inflammation Regulation
- Produce cytokines that help regulate the immune response and attract other immune cells to the site of inflammation
Parasite Defense
- Involved in the body’s defense against parasitic infections by releasing toxic granules that can damage or kill parasites
Interaction with Other Immune Cells
- Communicate with and modulate the activity of other leukocytes, particularly T-cells and eosinophils
Formation of Granules
- Contain granules filled with inflammatory mediators such as heparin (an anticoagulant) and histamine

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Specialty

immunology, Physiology

Keywords

Last edit:

2024-12-26 19:21:42

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