1. Definition
Dromotropic refers to the influence on the conduction velocity of electrical impulses through the heart’s conduction system, particularly the atrioventricular (AV) node. A positive dromotropic effect increases conduction speed, while a negative dromotropic effect slows down the conduction of impulses, affecting the heart’s rhythm and coordination.
2. Influencing factors
2.1. Substances with postive dromotropic effects
- Epinephrine (adrenaline)
- Norepinephrine (noradrenaline)
- Dopamine (at higher doses)
- Isoproterenol
- Dobutamine
- Atropine
2.2.Substances with negative dromotropic effects
- Beta-blockers (e.g., metoprolol, propranolol)
- Calcium channel blockers (e.g., verapamil, diltiazem)
- Digoxin
- Adenosine
- Amiodarone
- Ivabradine