1. Definition
Eosinophils are a type of white blood cell that play a crucial role in the immune response by combating parasitic infections, mediating allergic reactions, and regulating inflammation.
3. Physiology
- Absolute Count: This percentage corresponds to approximately 100 to 400 eosinophils per microliter (µL) of blood in a healthy individual
- Percentage in Blood: Eosinophils typically account for 1-4% of total white blood cells
- Eosinophilia: An increase in eosinophil count above the normal range
- Eosinopenia: A decrease in eosinophil count below the normal range
2. Function
Defense Against Parasites:
- larger parasites: helminths (worms)
- release toxic granules that damage or kill these invaders
Mediation of Allergic Reactions:
- allergic conditions like asthma and hay fever
- releasing inflammatory mediators such as histamines
- leukotrienes that contribute to tissue inflammation and hypersensitivity
Regulation of Immune Responses:
- help modulate the activity of other immune cells, maintaining a balanced immune response