Fc Receptor

Synonyms: FcR
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Table of Contents

1. Definition

Fc receptors are proteins found on the surface of various immune cells that bind to the Fc region of antibodies, facilitating processes like phagocytosis, antibody-dependent cellular cytotoxicity, and the regulation of immune responses.

2. Types of Fc Receptors

  • Fcγ Receptors (FcγR) – Bind to IgG antibodies:
    • FcγRI (CD64) – High affinity for IgG
    • FcγRIIA/B/C (CD32) – Intermediate affinity for IgG
    • FcγRIIIA/B (CD16) – Low affinity for IgG, involved in antibody-dependent cellular cytotoxicity (ADCC)
  • Fcε Receptors (FcεR) – Bind to IgE antibodies:
    • FcεRI – High affinity, primarily on mast cells, basophils, and eosinophils
    • FcεRII (CD23) – Low affinity, found on B cells and other immune cells
  • Fcα Receptors (FcαR) – Bind to IgA antibodies:
    • FcαRI (CD89) – Expressed on myeloid cells like monocytes and neutrophils
  • Fcμ Receptors (FcμR) – Bind to IgM antibodies
  • Fcα/μ Receptor (Fcα/μR) – Binds to both IgA and IgM antibodies
  • FcRn (Neonatal Fc Receptor) – Binds to IgG antibodies and albumin

3. Cells

  • Macrophages
  • Neutrophils
  • Eosinophils
  • Basophils
  • Mast Cells
  • Dendritic Cells
  • Natural Killer (NK) Cells
  • B cells
  • Monocytes
  • Platelets

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Cell Biology, immunology
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Last edit:
2024-12-26 19:22:04
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