1. Definition:
IgD is a poorly understood antibody that serves primarily as a receptor on B-cells and plays a role in initiating immune responses.
2. Characteristics and Function:
- Appearance: IgD is a monomeric antibody similar in structure to IgG, but with different functional properties.
- Function: It acts primarily as a B cell receptor (BCR), helping to activate B-cells when they encounter their specific antigen.
- Presence in serum: IgD is found at low levels in serum, and its precise function in the circulation is less well understood than that of other antibody classes.
- Mucosal Role: IgD may also play a role in mucosal immunity, but its specific functions in this context are still under investigation.
- B cell development: It is critical for the maturation and differentiation of B-cells, which helps the immune system respond to pathogens.