MHC class I

Julen Lux Baranano

edited by

Joshua Klemt,

1. Definition

MHC Class I molecules are cell surface proteins that present intracellularly derived peptides to cytotoxic CD8+ T cells, playing a important role in the immune system’s ability to detect and eliminate virus-infected and cancerous cells.

2. Function

Present peptides derived from intracellular proteins (e.g., viral proteins, tumor antigens)
Alert the immune system to infected or abnormal cells
Interact with cytotoxic T lymphocytes (CD8+ T cells), leading to the destruction of infected or cancerous cells

3. Expression

Found on all nucleated cells in the body
Especially abundant on cells that are targets for viral infections (e.g., epithelial cells, lymphocytes)

4. Peptide Source

Endogenously derived proteins, processed by the proteasome and transported into the endoplasmic reticulum (ER) by the TAP (Transporter associated with Antigen Processing) complex.

Was this article helpful?

Specialty

biology, histology, immunology

Keywords

Last edit:

2024-12-26 19:21:31

Important Notice

The content provided in DocAtlas is intended solely for educational and informational purposes. It is not a guide for diagnosis, treatment, or medical decision-making. As an open platform, the information in DocAtlas may be subject to inaccuracies, errors, or omissions, and it is important to review and cross-check all content with other reputable sources before making any medical or clinical decisions.

The material in DocAtlas does not replace professional medical advice, diagnosis, or treatment from qualified healthcare providers. Users should consult with their doctor, pharmacist, or other healthcare professionals for specific advice tailored to their individual conditions.

DocAtlas and its authors make no warranties regarding the completeness, accuracy, or reliability of the information contained within and are not liable for any harm, damage, or adverse effects arising from the use or misuse of the content. Users are responsible for ensuring that they verify and critically evaluate all information before applying it in any medical or clinical context.