MHC Class II

Synonyms: MHC class 2, MHC class 2 molecules, MHC type 2

Julen Lux Baranano

edited by

Joshua Klemt,

1. Definition
2. Function
3. Expression
4. Peptide Source

1. Definition

MHC Class II molecules are cell surface proteins that present extracellularly derived peptides to helper CD4+ T cells, essential for activating the adaptive immune response and coordinating immune system actions.

2. Function

Present peptides derived from extracellular proteins (e.g., bacterial toxins, extracellular pathogens)
Activate the adaptive immune system, specifically helper T cells (CD4+ T cells)
Help coordinate the immune response by activating various immune cells, such as B cells for antibody production and macrophages for enhanced pathogen destruction

3. Expression

Found primarily on professional antigen-presenting cells (APCs), such as:
- Dendritic cells
- Macrophages
- B cells
These cells are responsible for capturing, processing, and presenting antigens to helper T cells

4. Peptide Source

Derived from extracellular proteins that are engulfed by endocytosis or phagocytosis and processed within the endosome
Antigen peptides are loaded onto MHC class II molecules in the endosomal compartments after vesicle fusion

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Specialty

biology, histology, immunology

Keywords

Last edit:

2024-12-26 19:21:29

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