1. Definition
Neutrophils are a type of white blood cell (leukocyte) and belong to the granulocyte subclass, which contains granules filled with enzymes to destroy pathogens. They are the most abundant leukocytes, comprising 50-70% of all white blood cells in the bloodstream.
2. Functions
Neutrophils play a critical role in the innate immune system by being the first responders to sites of infection or injury.
- Phagocytosis: Neutrophils engulf and digest pathogens through the release of digestive enzymes from their granules
- Inflammation: They are key players in initiating the inflammatory response, which helps recruit more immune cells to the infection site
- Rapid Response: Neutrophils are the first immune cells to migrate to areas of acute infection or trauma, providing an immediate defense
3. Physiology
Neutrophilia: Neutrophil count above 7,500 cells/µL.
Neutropenia: Neutrophil count below 1,500 cells/µL.